Brian Finch discovers the brain-boosting power of the mysterious drug NZT and is coerced by the FBI into using his extraordinary cognitive abilities to solve complex cases for them. Working closely with Brian is Special Agent Rebecca Harris, a formidable investigator with a dark past, and Special Agent Boyle, a former military officer and Rebecca's confidante. They report to Special Agent in Charge Nasreen "Naz" Pouran, a canny manipulator of the reins of power. Unbeknownst to the FBI, Brian also has a clandestine relationship with Senator Edward Morra, a presidential hopeful and regular user of NZT who has plans of his own for his new protégé. Fueled now with a steady supply of NZT that enables him to use 100% of his brain capacity, Brian is more effective than all of the FBI agents combined, making him a criminal's worst nightmare and the greatest asset the Bureau has ever possessed. Following a stunning betrayal to their team, Brian and the FBI race to stop an NZT-enabled Sands and his associates from orchestrating an international incident. Also, Brian experiences devastating side effects when his NZT immunity starts to wear off. When NZT floods the streets of New York City and threatens to become a national epidemic, the FBI partners with the DOJ in a city-wide manhunt to find the lab producing the drug. Also, Brian has trouble adjusting to his new reality when he lacks the resources to continue searching for Piper. When Rebecca learns the truth about her father's death, she takes NZT for the first time and uses it to seek justice for his murder. Also, Sands makes a dangerous move against Brian to ensure the success of his new initiative. Brian’s double life unravels when Senator Morra makes contact just as Brian’s placed under 24-hour surveillance by the FBI following his rogue trip to Russia. Also, Mike and Ike tell an already suspicious Rebecca about Brian’s off-book interaction with Morra’s henchman, Sands. When Brian's closest relationships implode due to his inability to cut ties with Eddie Morra, he goes rogue from the FBI to free himself from the senator's control. In Russia, he searches for Piper, Morra's former associate turned adversary, and her alternative NZT vaccine. Also, Rebecca comes closer to discovering Brian's connection to NZT and Senator Morra.